CachyOS does compile packages with the x86-64-v3, x86-64-v4 and Zen4 instruction set and LTO to provide a higher performance. Core packages also get PGO or BOLT optimization.
CachyOS utilizes the BORE Scheduler for better interactivity, and offers a variety of scheduler options including EEVDF, sched-ext, ECHO, and RT. All kernels are compiled with optimized x86-64-v3, x86-64-v4, Zen4 instructions and LTO to be optimized for your CPU.
I like the sound of that for my new gaming distro, but I really feel more comfortable in the .deb ecosystem.
I don’t know of anything like what you’re looking for, but I have been using CachyOS for over a year now and I really like it. If you’re looking to get the most performance out of your machine for gaming I wouldn’t think you’d want such a stable release like Debian anyway.
Edit: like the other poster mentioned, I never did any testing or anything, but I also didn’t notice any major improvements when I switched from vanilla Arch to CachyOS to be fair.